1- Discovery Step:
It is consisting on the choice of therapeutic target and the identification and production of new active substance interacting with selected target. Such compound usually called as lead and originates from synthetic, organic, natural, semi synthetic or biotechnology process.
2- Optimization Step:
It deals with the improvement of an active compound this optimization process increase the potency, selectivity and decrease in toxicity. IT characteristics are the establishment of structurally active relationship. Ideally based on understanding of the molecular mode of action.
It deals with the improvement of an active compound this optimization process increase the potency, selectivity and decrease in toxicity. IT characteristics are the establishment of structurally active relationship. Ideally based on understanding of the molecular mode of action.
3- Development Step:
Its purpose in the continuation of the improvement of pharmacokinetic properties and the fine turning of pharmaceutics properties of active substance to make them suitable for clinical use. It can consist in preparation of better absorb compound of sustain release preparation and all water soluble derivatives or is the elimination of properties relating to the patient compliance e.g. irritation, painful injection, undesirable organoleptic properties.
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